New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells

The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion forming monometallic with formula [M(APZ-tBTSC)Cl]. three [Cu(APZ-tBTSC)Cl], [Pd(APZ-tBTSC)Cl], [Pt(APZ-tBTSC)Cl] were tested for anti-proliferative biological behavior panel of seven microbes, copper palladium found be highly active against Gram positive bacteria. 4 compounds also human topoisomerase IIα DNA relaxation assays all had inhibition at concentration between - 6 micro-molar. activity HEK293T cell line breast cancer line, MDA-MB-231. most effective compound was [Cu(APZ-tBTSC)Cl] complex, MDA-MB-231 complex.